{"id":4428,"date":"2025-08-16T19:45:55","date_gmt":"2025-08-16T16:15:55","guid":{"rendered":"https:\/\/hematomed.ir\/leukemia\/?p=4428"},"modified":"2025-08-16T19:45:57","modified_gmt":"2025-08-16T16:15:57","slug":"%d8%af%d8%b1%d9%85%d8%a7%d9%86-cml-treatment-of-cml","status":"publish","type":"post","link":"https:\/\/hematomed.ir\/leukemia\/%d8%af%d8%b1%d9%85%d8%a7%d9%86-cml-treatment-of-cml\/","title":{"rendered":"\u062f\u0631\u0645\u0627\u0646 CML (Treatment of CML)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><a>\u0647\u062f\u0641 \u062f\u0631\u0645\u0627\u0646<\/a>:<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u06a9\u0646\u062a\u0631\u0644 \u0628\u06cc\u0645\u0627\u0631\u06cc\u060c \u06a9\u0627\u0647\u0634 \u0628\u0627\u0631 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0698\u0646 BCR-ABL\u060c \u067e\u06cc\u0634\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0648\u0631\u0648\u062f \u0628\u0647 \u0641\u0627\u0632 \u0628\u0644\u0627\u0633\u062a\u060c \u0648 \u062f\u0631 \u0628\u0631\u062e\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u060c \u062a\u0648\u0642\u0641 \u062f\u0631\u0645\u0627\u0646 (Treatment-Free Remission)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>A<\/a>. \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u062a\u06cc\u0631\u0648\u0632\u06cc\u0646\u200c\u06a9\u06cc\u0646\u0627\u0632 (TKIs) \u2013 \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u0646\u0633\u0644<\/strong><strong><\/strong><\/td><td><strong>\u0648\u06cc\u0698\u06af\u06cc\u200c\u0647\u0627<\/strong><strong><\/strong><\/td><td><strong>\u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646\u200c\u0647\u0627<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Imatinib<\/strong><\/td><td>\u0627\u0648\u0644<\/td><td>\u0622\u063a\u0627\u0632\u06af\u0631 \u062f\u0631\u0645\u0627\u0646 \u0647\u062f\u0641\u0645\u0646\u062f\u061b \u067e\u0627\u0633\u062e \u062e\u0648\u0628 \u062f\u0631 \u0628\u06cc\u0634\u062a\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646<\/td><td>\u062e\u0637 \u0627\u0648\u0644<\/td><\/tr><tr><td><strong>Dasatinib<\/strong><\/td><td>\u062f\u0648\u0645<\/td><td>\u0646\u0641\u0648\u0630 CNS \u0628\u0647\u062a\u0631\u061b \u0645\u0624\u062b\u0631 \u062f\u0631 \u0645\u0642\u0627\u0648\u0645\u062a \u062e\u0641\u06cc\u0641<\/td><td>\u062e\u0637 \u0627\u0648\u0644 \u06cc\u0627 \u062f\u0648\u0645<\/td><\/tr><tr><td><strong>Nilotinib<\/strong><\/td><td>\u062f\u0648\u0645<\/td><td>\u062e\u0637\u0631 \u0639\u0648\u0627\u0631\u0636 \u0642\u0644\u0628\u06cc\u061b \u0642\u062f\u0631\u062a \u0628\u0627\u0644\u0627\u062a\u0631 \u0627\u0632 \u0627\u06cc\u0645\u0627\u062a\u06cc\u0646\u06cc\u0628<\/td><td>\u062e\u0637 \u0627\u0648\u0644 \u06cc\u0627 \u062f\u0648\u0645<\/td><\/tr><tr><td><strong>Bosutinib<\/strong><\/td><td>\u062f\u0648\u0645<\/td><td>GI-friendly\u061b \u0645\u0624\u062b\u0631 \u062f\u0631 \u0645\u0642\u0627\u0648\u0645\u062a \u0628\u0647 \u0627\u06cc\u0645\u0627\u062a\u06cc\u0646\u06cc\u0628<\/td><td>\u062e\u0637 \u062f\u0648\u0645<\/td><\/tr><tr><td><strong>Ponatinib<\/strong><\/td><td>\u0633\u0648\u0645<\/td><td>\u062a\u0646\u0647\u0627 \u062f\u0627\u0631\u0648\u06cc \u0645\u0624\u062b\u0631 \u0628\u0631 \u0645\u0648\u062a\u0627\u0633\u06cc\u0648\u0646 T315I<\/td><td>\u0645\u0648\u0627\u0631\u062f \u0645\u0642\u0627\u0648\u0645<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627\u06cc\u062f \u062a\u062d\u062a <strong>\u0645\u0627\u0646\u06cc\u062a\u0648\u0631\u06cc\u0646\u06af \u062f\u0642\u06cc\u0642<\/strong><strong> PCR <\/strong><strong>\u06a9\u0645\u06cc<\/strong><strong> BCR-ABL<\/strong> \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u0646\u062f (\u0647\u0631 3 \u0645\u0627\u0647)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a>B<\/a>. \u0627\u0647\u062f\u0627\u0641 \u062f\u0631\u0645\u0627\u0646\u06cc<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u0633\u0637\u062d \u067e\u0627\u0633\u062e<\/strong><strong><\/strong><\/td><td><strong>\u062a\u0639\u0631\u06cc\u0641<\/strong><strong><\/strong><\/td><td><strong>\u0632\u0645\u0627\u0646 \u0645\u0648\u0631\u062f \u0627\u0646\u062a\u0638\u0627\u0631<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>CHR<\/strong><\/td><td>\u0646\u0631\u0645\u0627\u0644 \u0634\u062f\u0646 CBC<\/td><td>\u062a\u0627 3 \u0645\u0627\u0647<\/td><\/tr><tr><td><strong>CCyR<\/strong><\/td><td>\u0639\u062f\u0645 \u0645\u0634\u0627\u0647\u062f\u0647 Ph+ \u062f\u0631 \u06a9\u0627\u0631\u06cc\u0648\u062a\u0627\u06cc\u067e<\/td><td>\u062a\u0627 6 \u0645\u0627\u0647<\/td><\/tr><tr><td><strong>MMR<\/strong><\/td><td>\u06a9\u0627\u0647\u0634 BCR-ABL \u0628\u0647 &lt;0.1%<\/td><td>\u062a\u0627 12 \u0645\u0627\u0647<\/td><\/tr><tr><td><strong>MR^4 <\/strong><strong>\u06cc\u0627<\/strong><strong> MR^4.5<\/strong><\/td><td>\u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0639\u0645\u06cc\u0642<\/td><td>&nbsp;\u226524 \u0645\u0627\u0647\u060c \u0634\u0631\u0637 \u062a\u0648\u0642\u0641 \u062f\u0631\u0645\u0627\u0646<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><a>C<\/a>. \u062a\u0648\u0642\u0641 \u062f\u0631\u0645\u0627\u0646 (Treatment-Free Remission \u2013 TFR)<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u2265\u06f2 \u0633\u0627\u0644 \u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0639\u0645\u06cc\u0642 \u062f\u0627\u0631\u0646\u062f<\/li>\n\n\n\n<li>\u0646\u06cc\u0627\u0632 \u0628\u0647 \u0645\u0627\u0646\u06cc\u062a\u0648\u0631\u06cc\u0646\u06af \u0634\u062f\u06cc\u062f \u0645\u0627\u0647\u0627\u0646\u0647 \u0628\u0627 PCR<\/li>\n\n\n\n<li>\u062f\u0631 \u0635\u0648\u0631\u062a \u0639\u0648\u062f\u060c \u0628\u0627\u0632\u06af\u0634\u062a \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 \u0628\u0627 TKI \u0645\u0639\u0645\u0648\u0644\u0627\u064b \u0645\u0624\u062b\u0631 \u0627\u0633\u062a<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a>D<\/a>. \u062f\u0631\u0645\u0627\u0646 \u0645\u0642\u0627\u0648\u0645 \u06cc\u0627 \u067e\u06cc\u0634\u0631\u0641\u062a\u0647<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u062f\u0631 \u0635\u0648\u0631\u062a \u0645\u0642\u0627\u0648\u0645\u062a \u0628\u0647 \u0686\u0646\u062f<\/strong><strong> TKI<\/strong><strong>:<\/strong> \u0628\u0631\u0631\u0633\u06cc \u0645\u0648\u062a\u0627\u0633\u06cc\u0648\u0646 ABL1<\/li>\n\n\n\n<li><strong>\u0645\u0648\u062a\u0627\u0633\u06cc\u0648\u0646<\/strong><strong> T315I<\/strong> : \u0641\u0642\u0637 \u0628\u0627 Ponatinib \u062f\u0631\u0645\u0627\u0646\u200c\u067e\u0630\u06cc\u0631<\/li>\n\n\n\n<li><strong>\u062f\u0631 \u0641\u0627\u0632 \u0628\u0644\u0627\u0633\u062a \u06cc\u0627 \u0634\u062a\u0627\u0628\u200c\u06cc\u0627\u0641\u062a\u0647<\/strong>:\n<ul class=\"wp-block-list\">\n<li>\u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc (\u0645\u0634\u0627\u0628\u0647 AML \u06cc\u0627 ALL)<\/li>\n\n\n\n<li>\u067e\u06cc\u0648\u0646\u062f \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0628\u0646\u06cc\u0627\u062f\u06cc \u062e\u0648\u0646\u0633\u0627\u0632 (HSCT) \u062f\u0631 \u0627\u0641\u0631\u0627\u062f \u062c\u0648\u0627\u0646 \u0648 \u0645\u0646\u0627\u0633\u0628<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a>E<\/a>. \u0639\u0648\u0627\u0631\u0636 \u062c\u0627\u0646\u0628\u06cc \u0631\u0627\u06cc\u062c TKIs<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u0639\u0648\u0627\u0631\u0636 \u0634\u0627\u06cc\u0639<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Imatinib<\/strong><\/td><td>\u062a\u0647\u0648\u0639\u060c \u0627\u062f\u0645\u060c \u06af\u0631\u0641\u062a\u06af\u06cc \u0639\u0636\u0644\u0627\u062a<\/td><\/tr><tr><td><strong>Dasatinib<\/strong><\/td><td>\u0627\u0641\u06cc\u0648\u0698\u0646 \u067e\u0644\u0648\u0631\u060c \u0627\u0641\u062a \u067e\u0644\u0627\u06a9\u062a<\/td><\/tr><tr><td><strong>Nilotinib<\/strong><\/td><td>\u0627\u0641\u0632\u0627\u06cc\u0634 \u062e\u0637\u0631 QT\u060c \u0627\u0641\u0632\u0627\u06cc\u0634 \u0644\u06cc\u067e\u06cc\u062f\u0647\u0627<\/td><\/tr><tr><td><strong>Ponatinib<\/strong><\/td><td>\u062a\u0631\u0648\u0645\u0628\u0648\u0632\u060c \u0641\u0634\u0627\u0631\u062e\u0648\u0646\u060c \u067e\u0627\u0646\u06a9\u0631\u0627\u062a\u06cc\u062a<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u0647\u062f\u0641 \u062f\u0631\u0645\u0627\u0646: \u06a9\u0646\u062a\u0631\u0644 \u0628\u06cc\u0645\u0627\u0631\u06cc\u060c \u06a9\u0627\u0647\u0634 \u0628\u0627\u0631 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0698\u0646 BCR-ABL\u060c \u067e\u06cc\u0634\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0648\u0631\u0648\u062f \u0628\u0647 \u0641\u0627\u0632 \u0628\u0644\u0627\u0633\u062a\u060c \u0648 \u062f\u0631 \u0628\u0631\u062e\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646\u060c \u062a\u0648\u0642\u0641 \u062f\u0631\u0645\u0627\u0646 (Treatment-Free Remission) A. \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u062a\u06cc\u0631\u0648\u0632\u06cc\u0646\u200c\u06a9\u06cc\u0646\u0627\u0632 (TKIs) \u2013 \u062f\u0631\u0645\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 \u062f\u0627\u0631\u0648 \u0646\u0633\u0644 \u0648\u06cc\u0698\u06af\u06cc\u200c\u0647\u0627 \u0627\u0646\u062f\u06cc\u06a9\u0627\u0633\u06cc\u0648\u0646\u200c\u0647\u0627 Imatinib \u0627\u0648\u0644 \u0622\u063a\u0627\u0632\u06af\u0631 \u062f\u0631\u0645\u0627\u0646 \u0647\u062f\u0641\u0645\u0646\u062f\u061b \u067e\u0627\u0633\u062e \u062e\u0648\u0628 \u062f\u0631 \u0628\u06cc\u0634\u062a\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u062e\u0637 \u0627\u0648\u0644 Dasatinib \u062f\u0648\u0645 \u0646\u0641\u0648\u0630 CNS \u0628\u0647\u062a\u0631\u061b \u0645\u0624\u062b\u0631 \u062f\u0631 \u0645\u0642\u0627\u0648\u0645\u062a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4428","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/comments?post=4428"}],"version-history":[{"count":1,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4428\/revisions"}],"predecessor-version":[{"id":4432,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4428\/revisions\/4432"}],"wp:attachment":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/media?parent=4428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/categories?post=4428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/tags?post=4428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}