{"id":4381,"date":"2025-08-16T19:25:01","date_gmt":"2025-08-16T15:55:01","guid":{"rendered":"https:\/\/hematomed.ir\/leukemia\/?p=4381"},"modified":"2025-08-16T19:25:04","modified_gmt":"2025-08-16T15:55:04","slug":"%d8%af%d8%b1%d9%85%d8%a7%d9%86%d9%87%d8%a7%db%8c-%d9%87%d8%af%d9%81%d9%85%d9%86%d8%af-%d8%af%d8%b1-aml-%d8%a8%d8%b1-%d8%a7%d8%b3%d8%a7%d8%b3-%d8%ac%d9%87%d8%b4%d9%87%d8%a7%db%8c","status":"publish","type":"post","link":"https:\/\/hematomed.ir\/leukemia\/%d8%af%d8%b1%d9%85%d8%a7%d9%86%d9%87%d8%a7%db%8c-%d9%87%d8%af%d9%81%d9%85%d9%86%d8%af-%d8%af%d8%b1-aml-%d8%a8%d8%b1-%d8%a7%d8%b3%d8%a7%d8%b3-%d8%ac%d9%87%d8%b4%d9%87%d8%a7%db%8c\/","title":{"rendered":"\u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f \u062f\u0631 AML \u0628\u0631 \u0627\u0633\u0627\u0633 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0698\u0646\u06cc"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\"><strong>&nbsp;<\/strong><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u06f1<\/a>. <strong>\u062c\u0647\u0634<\/strong><strong> FLT3<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u06cc\u06a9\u06cc \u0627\u0632 \u0634\u0627\u06cc\u0639\u200c\u062a\u0631\u06cc\u0646 \u062c\u0647\u0634\u200c\u0647\u0627 \u062f\u0631 AML \u0627\u0633\u062a \u0648 \u0628\u0647 \u062f\u0648 \u0646\u0648\u0639 \u062a\u0642\u0633\u06cc\u0645 \u0645\u06cc\u200c\u0634\u0648\u062f:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>FLT3-ITD (Internal Tandem Duplication)<\/strong><\/li>\n\n\n\n<li><strong>FLT3-TKD (Tyrosine Kinase Domain)<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><a>\u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f<\/a>:<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u062a\u0648\u0636\u06cc\u062d<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Midostaurin<\/strong><\/td><td>\u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0628\u0627 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062f\u0631 \u062e\u0637 \u0627\u0648\u0644 AML \u0628\u0627 FLT3-\u062c\u0647\u0634\u200c\u062f\u0627\u0631<\/td><\/tr><tr><td><strong>Gilteritinib<\/strong><\/td><td>\u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 AML \u0639\u0648\u062f \u06a9\u0631\u062f\u0647 \u06cc\u0627 \u0645\u0642\u0627\u0648\u0645 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 (Relapsed\/Refractory) \u0628\u0627 FLT3-\u062c\u0647\u0634\u200c\u062f\u0627\u0631<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u06f2<\/a>. <strong>\u062c\u0647\u0634<\/strong><strong> NPM1<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0634\u0627\u06cc\u0639\u200c\u062a\u0631\u06cc\u0646 \u062c\u0647\u0634 \u062f\u0631 AML \u0628\u0627 \u067e\u06cc\u0634\u200c\u0622\u06af\u0647\u06cc \u0646\u0633\u0628\u062a\u0627\u064b \u062e\u0648\u0628 (\u062f\u0631 \u063a\u06cc\u0627\u0628 FLT3-ITD)<\/li>\n\n\n\n<li>\u0647\u0646\u0648\u0632 \u062f\u0631\u0645\u0627\u0646 \u0647\u062f\u0641\u0645\u0646\u062f \u0645\u0633\u062a\u0642\u06cc\u0645 \u0646\u062f\u0627\u0631\u062f\u060c \u0627\u0645\u0627 \u062f\u0631 \u06a9\u0646\u0627\u0631 \u0633\u0627\u06cc\u0631 \u062c\u0647\u0634\u200c\u0647\u0627 \u0645\u0647\u0645 \u0627\u0633\u062a<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u06f3<\/a>. <strong>\u062c\u0647\u0634<\/strong><strong> IDH1 <\/strong><strong>\u0648<\/strong><strong> IDH2<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0627\u06cc\u0646 \u062c\u0647\u0634\u200c\u0647\u0627 \u0645\u0646\u062c\u0631 \u0628\u0647 \u062a\u0648\u0644\u06cc\u062f \u06cc\u06a9 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u062a \u0633\u0645\u06cc (2-HG) \u0645\u06cc\u200c\u0634\u0648\u0646\u062f \u06a9\u0647 \u062a\u0645\u0627\u06cc\u0632 \u0633\u0644\u0648\u0644\u200c\u0647\u0627 \u0631\u0627 \u0645\u0647\u0627\u0631 \u0645\u06cc\u200c\u06a9\u0646\u062f.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><a>\u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f<\/a>:<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u062c\u0647\u0634 \u0647\u062f\u0641<\/strong><strong><\/strong><\/td><td><strong>\u062a\u0648\u0636\u06cc\u062d<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Ivosidenib<\/strong><\/td><td>IDH1<\/td><td>\u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u062f\u0631 AML \u0639\u0648\u062f \u06a9\u0631\u062f\u0647 \u06cc\u0627 \u0645\u0642\u0627\u0648\u0645<\/td><\/tr><tr><td><strong>Enasidenib<\/strong><\/td><td>IDH2<\/td><td>\u0647\u0645\u0686\u0646\u06cc\u0646 \u062f\u0631 AML \u0645\u0642\u0627\u0648\u0645 \u06cc\u0627 \u0639\u0648\u062f\u06a9\u0631\u062f\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u06f4.<\/a> <strong>BCL-2 <\/strong><strong>\u0648\u0627\u0628\u0633\u062a\u0647 \u0628\u0648\u062f\u0646 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc<\/strong><strong> AML<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u0631\u062e\u06cc \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc AML \u0628\u0647 \u0628\u0642\u0627\u06cc \u0633\u0644\u0648\u0644\u06cc \u0627\u0632 \u0637\u0631\u06cc\u0642 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 BCL-2 \u0648\u0627\u0628\u0633\u062a\u0647 \u0647\u0633\u062a\u0646\u062f.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><a>\u062f\u0627\u0631\u0648<\/a>:<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u062a\u0648\u0636\u06cc\u062d<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Venetoclax<\/strong><\/td><td>\u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 BCL-2\u061b \u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0628\u0627 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0647\u06cc\u067e\u0648\u0645\u062a\u06cc\u0644\u0647\u200c\u06a9\u0646\u0646\u062f\u0647 (\u0645\u062b\u0644 Azacitidine \u06cc\u0627 Decitabine) \u0645\u062e\u0635\u0648\u0635\u0627\u064b \u062f\u0631 \u0633\u0627\u0644\u0645\u0646\u062f\u0627\u0646 \u06cc\u0627 \u0627\u0641\u0631\u0627\u062f \u0646\u0627\u062a\u0648\u0627\u0646 \u0628\u0647 \u06a9\u0627\u0631 \u0645\u06cc\u200c\u0631\u0648\u062f. \u062f\u0631\u0645\u0627\u0646 \u0645\u0624\u062b\u0631 \u062f\u0631 AML \u0628\u0627 NPM1 \u0648 IDH \u0645\u062b\u0628\u062a.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><a>\u06f5<\/a>. <strong>\u0645\u0627\u0631\u06a9\u0631 \u0633\u0637\u062d\u06cc<\/strong><strong> CD33<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062f\u0631 \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 AML\u060c \u0633\u0644\u0648\u0644\u200c\u0647\u0627 CD33 \u0631\u0627 \u0631\u0648\u06cc \u0633\u0637\u062d \u062e\u0648\u062f \u062f\u0627\u0631\u0646\u062f.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><a>\u062f\u0627\u0631\u0648<\/a>:<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u062f\u0627\u0631\u0648<\/strong><strong><\/strong><\/td><td><strong>\u062a\u0648\u0636\u06cc\u062d<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>Gemtuzumab ozogamicin (GO)<\/strong><\/td><td>\u0622\u0646\u062a\u06cc\u200c\u0628\u0627\u062f\u06cc \u0645\u0648\u0646\u0648\u06a9\u0644\u0648\u0646\u0627\u0644 \u0645\u062a\u0635\u0644 \u0628\u0647 \u062f\u0627\u0631\u0648\u06cc \u0633\u0645\u06cc\u061b \u0628\u0647 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc CD33+ \u0645\u062a\u0635\u0644 \u0634\u062f\u0647 \u0648 \u0628\u0627\u0639\u062b \u0645\u0631\u06af \u0622\u0646\u200c\u0647\u0627 \u0645\u06cc\u200c\u0634\u0648\u062f. \u062f\u0631 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647\u200c\u0647\u0627\u06cc \u062e\u0627\u0635 AML \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u06f1. \u062c\u0647\u0634 FLT3 \u06cc\u06a9\u06cc \u0627\u0632 \u0634\u0627\u06cc\u0639\u200c\u062a\u0631\u06cc\u0646 \u062c\u0647\u0634\u200c\u0647\u0627 \u062f\u0631 AML \u0627\u0633\u062a \u0648 \u0628\u0647 \u062f\u0648 \u0646\u0648\u0639 \u062a\u0642\u0633\u06cc\u0645 \u0645\u06cc\u200c\u0634\u0648\u062f: \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f: \u062f\u0627\u0631\u0648 \u062a\u0648\u0636\u06cc\u062d Midostaurin \u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0628\u0627 \u0634\u06cc\u0645\u06cc\u200c\u062f\u0631\u0645\u0627\u0646\u06cc \u062f\u0631 \u062e\u0637 \u0627\u0648\u0644 AML \u0628\u0627 FLT3-\u062c\u0647\u0634\u200c\u062f\u0627\u0631 Gilteritinib \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627 AML \u0639\u0648\u062f \u06a9\u0631\u062f\u0647 \u06cc\u0627 \u0645\u0642\u0627\u0648\u0645 \u0628\u0647 \u062f\u0631\u0645\u0627\u0646 (Relapsed\/Refractory) \u0628\u0627 FLT3-\u062c\u0647\u0634\u200c\u062f\u0627\u0631 \u06f2. \u062c\u0647\u0634 NPM1 \u06f3. \u062c\u0647\u0634 IDH1 \u0648 IDH2 \u0627\u06cc\u0646 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4381","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4381","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/comments?post=4381"}],"version-history":[{"count":1,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4381\/revisions"}],"predecessor-version":[{"id":4382,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4381\/revisions\/4382"}],"wp:attachment":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/media?parent=4381"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/categories?post=4381"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/tags?post=4381"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}