{"id":4303,"date":"2025-08-16T18:54:32","date_gmt":"2025-08-16T15:24:32","guid":{"rendered":"https:\/\/hematomed.ir\/leukemia\/?p=4303"},"modified":"2025-08-16T18:54:48","modified_gmt":"2025-08-16T15:24:48","slug":"%d9%be%db%8c%da%af%db%8c%d8%b1%db%8c-cml","status":"publish","type":"post","link":"https:\/\/hematomed.ir\/leukemia\/%d9%be%db%8c%da%af%db%8c%d8%b1%db%8c-cml\/","title":{"rendered":"\u067e\u06cc\u06af\u06cc\u0631\u06cc CML"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><a><strong>\u0631\u0627\u0647\u0646\u0645\u0627\u06cc \u067e\u06cc\u06af\u06cc\u0631\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647<\/strong><\/a><strong> CML<\/strong><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><a><strong>\u0627\u0647\u062f\u0627\u0641 \u067e\u06cc\u06af\u06cc\u0631\u06cc<\/strong><\/a><strong>:<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u0628\u0631\u0631\u0633\u06cc <strong>\u067e\u0627\u0633\u062e \u0647\u0645\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u06a9\u060c \u0633\u06cc\u062a\u0648\u0698\u0646\u062a\u06cc\u06a9 \u0648 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc<\/strong><\/li>\n\n\n\n<li>\u0634\u0646\u0627\u0633\u0627\u06cc\u06cc <strong>\u0645\u0642\u0627\u0648\u0645\u062a \u062f\u0627\u0631\u0648\u06cc\u06cc \u06cc\u0627 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc<\/strong><strong> BCR-ABL<\/strong><\/li>\n\n\n\n<li>\u06a9\u0646\u062a\u0631\u0644 <strong>\u0639\u0648\u0627\u0631\u0636 \u062c\u0627\u0646\u0628\u06cc \u062f\u0631\u0645\u0627\u0646<\/strong><strong> <\/strong><strong>(\u0628\u0647\u200c\u0648\u06cc\u0698\u0647<\/strong><strong> TKIs<\/strong><strong>)<\/strong><\/li>\n\n\n\n<li>\u0628\u0631\u0631\u0633\u06cc \u0627\u0645\u06a9\u0627\u0646 <strong>\u06a9\u0627\u0647\u0634 \u06cc\u0627 \u0642\u0637\u0639 \u062f\u0631\u0645\u0627\u0646 \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u062e\u0627\u0635<\/strong><\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><a><strong>\u0632\u0645\u0627\u0646\u200c\u0628\u0646\u062f\u06cc \u067e\u06cc\u06af\u06cc\u0631\u06cc\u200c\u0647\u0627<\/strong><\/a><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u0645\u0627\u0647\u200c\u0647\u0627\u06cc \u0627\u0648\u0644 \u062f\u0631\u0645\u0627\u0646<\/strong><strong>:<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u0632\u0645\u0627\u0646<\/strong><strong><\/strong><\/td><td><strong>\u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>\u0647\u0631 \u0645\u0627\u0647<\/strong><\/td><td>CBC \u0628\u0631\u0627\u06cc \u0628\u0631\u0631\u0633\u06cc \u067e\u0627\u0633\u062e \u0647\u0645\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u06a9<\/td><\/tr><tr><td><strong>\u0647\u0631 3 \u0645\u0627\u0647<\/strong><\/td><td>PCR \u0628\u0631\u0627\u06cc BCR-ABL1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>\u0628\u0639\u062f \u0627\u0632 12 \u0645\u0627\u0647<\/strong><strong>:<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u067e\u0627\u0633\u062e \u062f\u0631\u0645\u0627\u0646\u06cc \u067e\u0627\u06cc\u062f\u0627\u0631<\/strong><strong><\/strong><\/td><td><strong>\u067e\u06cc\u06af\u06cc\u0631\u06cc<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td>\u0627\u06af\u0631 PCR &lt; 0.1% (MR3 \u06cc\u0627 \u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u06a9\u0627\u0645\u0644)<\/td><td>\u0647\u0631 3 \u062a\u0627 6 \u0645\u0627\u0647 \u06cc\u06a9\u200c\u0628\u0627\u0631 PCR<\/td><\/tr><tr><td>\u0627\u06af\u0631 \u067e\u0627\u0633\u062e \u0646\u0627\u0642\u0635 \u0628\u0627\u0634\u062f<\/td><td>\u0628\u0631\u0631\u0633\u06cc \u0645\u062c\u062f\u062f \u062c\u0647\u0634\u200c\u0647\u0627\u060c \u062a\u063a\u06cc\u06cc\u0631 \u062f\u0627\u0631\u0648\u060c \u0627\u062d\u062a\u0645\u0627\u0644 \u0628\u06cc\u0648\u067e\u0633\u06cc \u0645\u063a\u0632 \u0627\u0633\u062a\u062e\u0648\u0627\u0646<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><a><strong>\u0627\u0646\u0648\u0627\u0639 \u067e\u0627\u0633\u062e \u062f\u0631\u0645\u0627\u0646\u06cc \u06a9\u0647 \u067e\u0627\u06cc\u0634 \u0645\u06cc\u200c\u0634\u0648\u0646\u062f<\/strong><\/a><strong>:<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>\u0646\u0648\u0639 \u067e\u0627\u0633\u062e<\/strong><strong><\/strong><\/td><td><strong>\u0645\u0639\u06cc\u0627\u0631\u0647\u0627<\/strong><strong><\/strong><\/td><\/tr><\/thead><tbody><tr><td><strong>\u067e\u0627\u0633\u062e \u0647\u0645\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u06a9 \u06a9\u0627\u0645\u0644<\/strong><strong> (CHR)<\/strong><\/td><td>\u0646\u0631\u0645\u0627\u0644 \u0634\u062f\u0646 \u0634\u0645\u0627\u0631\u0634 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u062e\u0648\u0646 \u0645\u062d\u06cc\u0637\u06cc + \u0639\u062f\u0645 \u0628\u0632\u0631\u06af\u06cc \u0637\u062d\u0627\u0644<\/td><\/tr><tr><td><strong>\u067e\u0627\u0633\u062e \u0633\u06cc\u062a\u0648\u0698\u0646\u062a\u06cc\u06a9 \u06a9\u0627\u0645\u0644<\/strong><strong> (CCyR)<\/strong><\/td><td>\u0646\u0628\u0648\u062f \u06a9\u0631\u0648\u0645\u0648\u0632\u0648\u0645 \u0641\u06cc\u0644\u0627\u062f\u0644\u0641\u06cc\u0627 \u062f\u0631 \u06a9\u0627\u0631\u06cc\u0648\u062a\u0627\u06cc\u067e<\/td><\/tr><tr><td><strong>\u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc<\/strong><strong> <\/strong><strong>(<\/strong><strong>MMR <\/strong><strong>\u06cc\u0627<\/strong><strong> DMR<\/strong><strong>)<\/strong><\/td><td>\u06a9\u0627\u0647\u0634 BCR-ABL \u0628\u0647 &lt; 0.1% (\u0628\u0627 PCR \u06a9\u0645\u06cc)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><a><strong>\u067e\u0627\u06cc\u0634 \u0628\u0627<\/strong><\/a><strong> RT-PCR (Quantitative PCR)<\/strong><strong>:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062d\u0633\u0627\u0633\u200c\u062a\u0631\u06cc\u0646 \u0631\u0648\u0634 \u067e\u0627\u06cc\u0634 \u067e\u0627\u0633\u062e \u062f\u0631\u0645\u0627\u0646\u06cc<\/li>\n\n\n\n<li>\u0647\u062f\u0641: \u0631\u0633\u06cc\u062f\u0646 \u0628\u0647 <strong>\u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0639\u0645\u062f\u0647<\/strong><strong> (MMR)<\/strong> \u062f\u0631 \u0633\u0627\u0644 \u0627\u0648\u0644<\/li>\n\n\n\n<li>\u062a\u06a9\u0631\u0627\u0631: \u0647\u0631 3 \u0645\u0627\u0647 \u062a\u0627 \u0631\u0633\u06cc\u062f\u0646 \u0628\u0647 MMR\u060c \u0633\u067e\u0633 \u0647\u0631 6 \u0645\u0627\u0647<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><strong>\u0686\u0647 \u0632\u0645\u0627\u0646\u06cc \u0628\u0627\u06cc\u062f \u0628\u0647 \u062a\u063a\u06cc\u06cc\u0631 \u062f\u0631\u0645\u0627\u0646 \u0641\u06a9\u0631 \u06a9\u0631\u062f\u061f<\/strong><\/a><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0627\u0641\u0632\u0627\u06cc\u0634 \u0645\u06a9\u0631\u0631 BCR-ABL \u062f\u0631 PCR<\/li>\n\n\n\n<li>\u0646\u0631\u0633\u06cc\u062f\u0646 \u0628\u0647 \u067e\u0627\u0633\u062e \u0645\u0637\u0644\u0648\u0628 \u0637\u0628\u0642 \u062c\u062f\u0648\u0644 \u0632\u0645\u0627\u0646\u200c\u0628\u0646\u062f\u06cc<\/li>\n\n\n\n<li>\u0639\u0648\u0627\u0631\u0636 \u063a\u06cc\u0631\u0642\u0627\u0628\u0644 \u062a\u062d\u0645\u0644 \u0627\u0632 \u062f\u0627\u0631\u0648<\/li>\n\n\n\n<li>\u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0645\u0642\u0627\u0648\u0645 \u0645\u0627\u0646\u0646\u062f <strong>T315I<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u2b05 \u062f\u0631 \u0627\u06cc\u0646 \u0645\u0648\u0627\u0631\u062f\u060c \u062f\u0627\u0631\u0648\u06cc TKI \u0628\u0627\u06cc\u062f \u062a\u063a\u06cc\u06cc\u0631 \u06cc\u0627\u0628\u062f (\u0645\u062b\u0644\u0627\u064b ponatinib \u0628\u0631\u0627\u06cc T315I)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><a><strong>\u0646\u06a9\u062a\u0647 \u062f\u0631\u0628\u0627\u0631\u0647 \u0642\u0637\u0639 \u062f\u0631\u0645\u0627\u0646<\/strong><\/a><strong> (TKI Discontinuation)<\/strong><strong>:<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062f\u0631 \u0628\u0631\u062e\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u06a9\u0647:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0628\u06cc\u0634 \u0627\u0632 3 \u0633\u0627\u0644 \u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0639\u0645\u06cc\u0642 \u067e\u0627\u06cc\u062f\u0627\u0631<\/strong><strong> <\/strong><strong>(<\/strong><strong>MR4 <\/strong><strong>\u06cc\u0627 \u0628\u06cc\u0634\u062a\u0631)<\/strong> \u062f\u0627\u0631\u0646\u062f<\/li>\n\n\n\n<li>\u0648 <strong>\u062a\u0645\u0627\u06cc\u0644 \u062f\u0627\u0631\u0646\u062f \u062f\u0627\u0631\u0648 \u0631\u0627 \u0642\u0637\u0639 \u06a9\u0646\u0646\u062f<\/strong><br>\u2b05 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u062f\u0631\u0645\u0627\u0646 \u0631\u0627 \u0628\u0627 \u0646\u0638\u0627\u0631\u062a \u062f\u0642\u06cc\u0642 \u0642\u0637\u0639 \u06a9\u0631\u062f (TKI cessation)<br>\u0648\u0644\u06cc \u062f\u0631 \u0627\u06cc\u0646 \u0635\u0648\u0631\u062a \u0628\u0627\u06cc\u062f <strong>PCR <\/strong><strong>\u0647\u0631 \u0645\u0627\u0647 \u062a\u0627 6 \u0645\u0627\u0647<\/strong> \u0648 \u0633\u067e\u0633 \u0647\u0631 2 \u0645\u0627\u0647 \u0627\u0646\u062c\u0627\u0645 \u0634\u0648\u062f.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><a><strong>\u0627\u0631\u0632\u06cc\u0627\u0628\u06cc\u200c\u0647\u0627\u06cc \u062a\u06a9\u0645\u06cc\u0644\u06cc \u062f\u0631 \u0647\u0631 \u0648\u06cc\u0632\u06cc\u062a<\/strong><\/a><strong>:<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0628\u0631\u0631\u0633\u06cc \u0639\u0648\u0627\u0631\u0636 \u062c\u0627\u0646\u0628\u06cc (\u0627\u062f\u0645\u060c \u062f\u0631\u062f \u0639\u0636\u0644\u0627\u0646\u06cc\u060c \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0642\u0646\u062f \u06cc\u0627 \u0686\u0631\u0628\u06cc \u062e\u0648\u0646)<\/li>\n\n\n\n<li>\u0628\u0631\u0631\u0633\u06cc \u0639\u0645\u0644\u06a9\u0631\u062f \u06a9\u0628\u062f \u0648 \u06a9\u0644\u06cc\u0647<\/li>\n\n\n\n<li>\u0646\u0648\u0627\u0631 \u0642\u0644\u0628 \u062f\u0631 \u0635\u0648\u0631\u062a \u0645\u0635\u0631\u0641 nilotinib (\u062e\u0637\u0631 \u0637\u0648\u0644\u0627\u0646\u06cc \u0634\u062f\u0646 QT)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0631\u0627\u0642\u0628\u062a \u062a\u0633\u06a9\u06cc\u0646\u06cc (Palliative Care) \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u0644\u0648\u0633\u0645\u06cc \u0645\u06cc\u0644\u0648\u0626\u06cc\u062f \u0645\u0632\u0645\u0646 (CML) \u0628\u062e\u0634 \u0645\u0647\u0645\u06cc \u0627\u0632 \u0645\u062f\u06cc\u0631\u06cc\u062a \u062c\u0627\u0645\u0639 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0627\u0633\u062a\u060c \u0628\u0647\u200c\u0648\u06cc\u0698\u0647 \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u06cc\u0627 \u0645\u0648\u0627\u0631\u062f\u06cc \u06a9\u0647 \u062f\u0631\u0645\u0627\u0646 \u0647\u062f\u0641\u0645\u0646\u062f (TKI) \u062f\u06cc\u06af\u0631 \u0645\u0624\u062b\u0631 \u0646\u06cc\u0633\u062a \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631 \u062a\u062d\u0645\u0644 \u062f\u0631\u0645\u0627\u0646 \u0631\u0627 \u0646\u062f\u0627\u0631\u062f.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0631\u0627\u0647\u0646\u0645\u0627\u06cc \u067e\u06cc\u06af\u06cc\u0631\u06cc \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 CML \u0627\u0647\u062f\u0627\u0641 \u067e\u06cc\u06af\u06cc\u0631\u06cc: \u0632\u0645\u0627\u0646\u200c\u0628\u0646\u062f\u06cc \u067e\u06cc\u06af\u06cc\u0631\u06cc\u200c\u0647\u0627 \u0645\u0627\u0647\u200c\u0647\u0627\u06cc \u0627\u0648\u0644 \u062f\u0631\u0645\u0627\u0646: \u0632\u0645\u0627\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627 \u0647\u0631 \u0645\u0627\u0647 CBC \u0628\u0631\u0627\u06cc \u0628\u0631\u0631\u0633\u06cc \u067e\u0627\u0633\u062e \u0647\u0645\u0627\u062a\u0648\u0644\u0648\u0698\u06cc\u06a9 \u0647\u0631 3 \u0645\u0627\u0647 PCR \u0628\u0631\u0627\u06cc BCR-ABL1 \u0628\u0639\u062f \u0627\u0632 12 \u0645\u0627\u0647: \u067e\u0627\u0633\u062e \u062f\u0631\u0645\u0627\u0646\u06cc \u067e\u0627\u06cc\u062f\u0627\u0631 \u067e\u06cc\u06af\u06cc\u0631\u06cc \u0627\u06af\u0631 PCR &lt; 0.1% (MR3 \u06cc\u0627 \u067e\u0627\u0633\u062e \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u06a9\u0627\u0645\u0644) \u0647\u0631 3 \u062a\u0627 6 \u0645\u0627\u0647 \u06cc\u06a9\u200c\u0628\u0627\u0631 PCR \u0627\u06af\u0631 \u067e\u0627\u0633\u062e \u0646\u0627\u0642\u0635 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-4303","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/comments?post=4303"}],"version-history":[{"count":1,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4303\/revisions"}],"predecessor-version":[{"id":4307,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/posts\/4303\/revisions\/4307"}],"wp:attachment":[{"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/media?parent=4303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/categories?post=4303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hematomed.ir\/leukemia\/wp-json\/wp\/v2\/tags?post=4303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}